Synthesis of Aminophenoxazinones and Evaluation of Their Phytotoxicity in the Search for New Natural Herbicides

Natural products have been postulated as an alternative to the use of synthetic herbicides in pest control. The latter compounds caused numerous problems and these include appearance resistance such herbicides. Aminophenoxazinones are natural that shown multiple biological activities, pharmacological or phytotoxic effects. In case phytotoxicity, mode action aminophenoxazinones has not widely exploited agriculture resistant weeds reported date. This fact makes promising candidates development study here, seven aminophenoxazinone derivatives synthesized their phytotoxicity evaluated on wheat coleoptiles two important agricultural (Lolium rigidum Portulaca oleracea). Several activity, which is similar positive control pendimethalin, even higher some cases at highest concentrations tested. most affected parameter was root length susceptible weed P. oleracea. Compound 2, nitrogen atoms present heterocycles, active this followed by compound 1. Modifications C-8 led a reduced with exception nitro However, also increased introducing iodo-substituent C-4. results highlight